Nathan Pharma Pvt. Ltd.

RABEPRAZOLE + DOMPERIDONE is a gastrointestinal medicine composed of Rabeprazole (stomach acid reducer) and Domperidone (nausea/vomiting reducer). Together they reduce the amount of acid your stomach makes and decrease the symptoms of nausea and vomiting

Rabeprazole & Levosulpiride Capsule is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

• Irritable Bowel Syndrome.
• Indigestion.
• Gastroesophageal Reflux Disease.
• Mental Disorder.
• Depression.
• Frequent Persistent Heartburn.
• Gastric Acidity.
• Gastro-Intestinal Reflux

Having a positive quality management system, we are involved in presenting a comprehensive compilation of Cholecalciferol Alrol Softgel Capsules.

 

Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin when exposed to sunlight, it also found in some foods and can be taken as a dietary supplement. It is used to treat and prevent vitamin D deficiency and associated diseases, including rickets.

It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. It is usually taken by mouth.

Excessive doses can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Normal doses are safe in pregnancy. It may not be effective in people with severe kidney disease.

 

Cholecalciferol is made in the skin following UVB light exposure. It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase the uptake of calcium by the intestines. It is found in food such as some fish, cheese, and eggs. Certain foods such as milk have cholecalciferol added to them in some countries.

Cholecalciferol was first described in 1936. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Mechanism of action:

The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mitochondrial sterol 27-hydroxylase catalyses the first reaction in the oxidation of the side chain of sterol intermediates. The active form of vitamin D3 (calcitriol) binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium.

Metabolism:
Within the liver, cholecalciferal is hydroxylated to calcidiol (25-hydroxycholecalciferol) by the enzyme 25-hydroxylase. Within the kidney, calcidiol serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D3.

Indication:
For the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.

Uses of Cholecalciferol, 60000 IU Capsule:

• Nutritional Supplementation
• Osteoporosis
• Hypoparathyroidism
• Vitamin D Resistant Rickets
• Familial Hypophosphatemia

Indication:

• Blastomycosis
• Histoplasmosis
• Aspergillosis - Aspergilloma
• Aspergillosis - Invasive
• Oral Thrush
• Esophageal Candidiasis
• Onychomycosis - Toenail
• Onychomycosis - Fingernail
• Coccidioidomycosis
• Sporotrichosis
• Cryptococcosis
• Cryptococcal Meningitis - Immunosuppressed Host
• Vaginal Candidiasis
• Microsporidiosis
• Systemic Fungal Infection
• Fungal Infection Prophylaxis
• Tinea Versicolor
• Paracoccidioidomycosis

Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.